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. 2013 Apr 18;4(4):382–392. doi: 10.1111/jdi.12063

Figure 5.

image

Effect of exendin‐4 on the ex vivo production of superoxide anion in culture supernatant of peripheral blood mononuclear cells (PBMC) from type 2 diabetes patients and control subjects. PBMC culture was incubated with or without exendin‐4 at 50 nmol/L for 24 h, with or without pretreatment with U0126 (U0126 10 μmol/L), SP600125 (SP 10 μmol/K) and SB203580 (SB 10 μmol/L) for 1 h. Culture supernatants were then harvested for the assay of superoxides. Results are presented with box‐and‐whisker plots. *P < 0.05. CTL, control; DMSO, dimethyl sulfoxide; T2DM, type 2 diabetes.