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. 2014 May 12;9:4. doi: 10.1186/1750-2187-9-4

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Copyright © 2014 Takács-Vellai; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Domain organization of the worm KSR proteins related to murine KSR1. KSR proteins consist of five conserved areas (CA): CA1 (KSR-specific domain), CA2 (proline-rich region), CA3 (cysteine-rich region), CA4 (serine/threonine-rich region), CA5 (kinase-like domain). C. elegans (C.e.) KSR-1 and KSR-2A lack the CA1 domain. Worm KSR-1 lacks the CA2 domain, whereas in KSR-2A the CA4 domain with the FXFP motif (ERK/MAPK docking site) is absent. 14-3-3 binding sites Ser297 (S*) and Ser392 (S* marked red) located on either side of the CA3 domain in the mouse protein (mKSR1) are absent in the worm proteins.