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. 2014 May 2;12:110. doi: 10.1186/1479-5876-12-110

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Copyright © 2014 Schon et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Design and application of MSC-loaded surgical mesh. A: Composition of MSC-loading mesh. B: Distribution of MSCs in the PGA-based scaffold. MSCs (green) were labeled with fluorescent dye SYTO®10. PGA fibers also showed green in auto-fluorescence (bar = 50 μm). C: The MSC-loaded mesh was used to repair the 3-mm defect (between the dot lines) created at the junction of Achilles tendon and gastrocnemius/soleus. The portion of scaffold/MSCs was inserted into the defect and surgical mesh was sutured to the surface of muscle and tendon (black arrowhead indicates a knot of surgical suture used to tie the scaffold and surgical mesh together. The suture was melted after autoclave).