Table 3. Odds ratios of colorectal adenoma according to quartiles of fasting serum insulin.
| Insulin, μIU/mL (median) | OR (95% CI) | P for trends | |||
|---|---|---|---|---|---|
| Q1 | Q2 | Q3 | Q4 | ||
| <3.6 (2.49) | 3.6 –5.3 (4.39) | 5.3 –7.6 (6.30) | >7.6 (11.1) | ||
| Univariate | 1.0 (ref) | 1.20 (1.07–1.35)a | 1.20 (1.06 –1.35)a | 1.50 (1.33–1.69)a | <0.05 |
| Model 1 | 1.0 (ref) | 1.17 (1.03–1.34)a | 1.19 (1.04–1.36)a | 1.42 (1.25 –1.62)a | <0.05 |
| Model 2 | 1.0 (ref) | 1.10 (0.96 –1.26) | 1.06 (0.92–1.22) | 1.17 (1.01–1.35)a | NS (P = 0.07) |
a
P < 0.05. Model 1: Adjusted for age, sex, current smoking, alcohol drinking, family history of colorectal cancer. Model 2: Further adjusted for body mass index. CI, confidence interval; NS, not significant; OR, odds ratio; Q, quartile.