Table 5. Odds ratio of colorectal adenoma according to quartiles of fasting serum insulin stratified by fasting blood glucose.
| OR (95% CI) | P for trends | ||||
|---|---|---|---|---|---|
| FBS < 100 mg/dL | Q1 | Q2 | Q3 | Q4 | |
| Insulin, μIU/mL (median) | <3.3 (2.29) | 3.3–4.7 (4.03) | 4.7–6.6 (5.62) | >6.6 (9.57) | |
| Adenoma cases/non–cases | 516/1,130 | 529/1,025 | 520/954 | 557/985 | |
| Univariate | 1.0 (ref) | 1.13 (0.98 –1.31) | 1.19 (1.03 –1.39)a | 1.24 (1.07 –1.44)a | <0.05 |
| Model 1 | 1.0 (ref) | 1.14 (0.97 –1.34) | 1.22 (1.04 –1.44)a | 1.21 (1.03 –1.42)a | <0.05 |
| Model 2 | 1.0 (ref) | 1.06 (0.90 –1.25) | 1.09 (0.92 –1.30) | 0.99 (0.83 –1.18) | NS |
| FBS ≥ 100 mg/dL | Q1 | Q2 | Q3 | Q4 | P for trends |
|---|---|---|---|---|---|
| Insulin, μIU/mL (median) | <4.7 (3.53) | 4.7–6.5 (5.62) | 6.5–9.4 (7.84) | >9.4 (13.39) | |
| Adenoma cases/non‐cases | 360/509 | 340/499 | 372/493 | 412/424 | |
| Univariate | 1.0 (ref) | 0.96 (0.79 –1.17) | 1.07 (0.88 –1.29) | 1.37 (1.14 –1.66)a | <0.05 |
| Model 1 | 1.0 (ref) | 1.13 (0.91 –1.40) | 1.25 (1.01 –1.54)a | 1.70 (1.37 –2.10)a | <0.05 |
| Model 2 | 1.0 (ref) | 1.08 (0.87 –1.34) | 1.15 (0.93 –1.42) | 1.47 (1.17 –1.87)a | <0.05 |
a
P < 0.05. Model 1: Adjusted for age, sex, current smoking, alcohol drinking, family history of colorectal cancer. Model 2: Further adjusted for body mass index. CI, confidence interval; FBS, fasting blood sugar; NS, not significant; OR, odds ratio; Q, quartile; ref, reference.