Table 6. Odds ratios of colorectal adenoma according to quartiles of fasting serum insulin stratified by body mass index.
| OR (95% CI) | P for trend | ||||
|---|---|---|---|---|---|
| BMI < 25 kg/m2 | Q1 | Q2 | Q3 | Q4 | |
| Insulin, μIU/mL (median) | <3.2 (2.25) | 3.2 – 4.6 (3.92) | 4.6 – 6.5 (5.49) | >6.5 (9.19) | |
| Adenoma cases/non‐cases | 513/1,103 | 503/1,054 | 514/1,053 | 545/950 | |
| Univariate | 1.0 (ref) | 1.03 (0.88 –1.19) | 1.05 (0.91 –1.22) | 1.23 (1.06 –1.43)a | <0.05 |
| Model 1 | 1.0 (ref) | 1.08 (0.92 –1.28) | 1.11 (0.94 –1.31) | 1.26 (1.07 –1.49)a | <0.05 |
| BMI ≥ 25 kg/m2 | Q1 | Q2 | Q3 | Q4 | P for trend |
|---|---|---|---|---|---|
| Insulin, μIU/mL (median) | <4.9 (3.74) | 4.9 – 6.8 (5.89) | 6.8 – 9.7 (8.15) | >9.7 (13.89) | |
| Adenoma cases/non‐cases | 403/464 | 365/482 | 369/464 | 394/449 | |
| Univariate | 1.0 (ref) | 0.87 (0.72 –1.05) | 0.92 (0.76 –1.12) | 1.01 (0.84 –1.22) | NS |
| Model 1 | 1.0 (ref) | 0.95 (0.77 –1.17) | 1.01 (0.82 –1.24) | 1.13 (0.92 –1.39) | NS |
a
P < 0.05. Model 1: Adjusted for age, sex, current smoking, alcohol drinking, family history of colorectal cancer. CI, confidence interval; NS, not significant; OR, odds ratio; Q, quartile.