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The mRNA expression of IL-1β, iNOS, and COX2 of intervertebral discs from the 7-month groups. Compared with control groups, upright posture increased mRNA expression of IL-1β, iNOS, and COX2 significantly, but ligustrazine and meloxicam pretreatment downregulated those gene expression. The columns represent the mean ± SD of three independent experiments. *P < 0.05 compared to model group.
