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. 2014 Apr 27;2014:214353. doi: 10.1155/2014/214353

Table 1.

Well-known associations with Charcot foot, based on 388 patients with Charcot foot. Although not all associations presented here show a significant temporal relationship with Charcot foot, those that do preceded the diagnosis of Charcot foot.

Disease category ICD-9 code ICD-9 description Number (%) with both disorders Association odds ratio Association P value Temporal P value
Endocrine, nutritional and metabolic diseases, and immunity disorders 250.00* Type 2 diabetes mellitus 243 (62.6) 55.4 <5 ×  10−324 8.5 × 10−37
278.00 Obesity 52 (13.4) 11.7 2.4 × 10−95 4.1 × 10−4

Nervous system 356.9 Peripheral neuropathy 161 (41.5) 101.2 <5 ×  10−324 3.9 × 10−12

Blood and blood-forming organs 280.0 Anemia due to chronic blood loss 16 (4.1) 9.9 1.0 × 10−26 0.80
285.9 Anemia, not otherwise specified 98 (25.3) 14.9 3.3 × 10−205 0.085
285.29 Anemia of other chronic diseases 10 (2.6) 43.1 1.1 × 10−79 1
280.9 Iron deficiency anemia 32 (8.2) 14.5 1.5 × 10−79 0.60

Skin and subcutaneous tissue 682.6 Cellulitis/abscess of leg 87 (22.4) 41.9 <5 ×  10−324 4.4 × 10−6
682.7 Cellulitis/abscess of foot 98 (25.3) 133.8 <5 ×  10−324 5.5 × 10−6

Genitourinary system 593.9 Renal & ureteral disorder, not otherwise specified 119 (30.7) 20.9 <5 ×  10−324 4.5 × 10−4
585 Chronic kidney disease 64 (16.5) 29.4 7.7 × 10−314 2.4 × 10−5

Musculoskeletal system and connective tissue 714.0 Rheumatoid arthritis 37 (9.5) 13.5 1.2 × 10−83 1.3 × 10−5
733.00 Osteoporosis 44 (11.3) 12.1 4.4 × 10−86 0.29
733.90 Bone/cartilage disorder, not otherwise specified 233 (60.1) 26.0 <5 ×  10−324 5.9 × 10−12

Injury and poisoning 996.81 Complication of kidney transplant 44 (11.3) 43.3 <5 ×  10−324 3.9 × 10−4

External causes of injury and supplemental classification V42.0 Kidney transplant 50 (12.9) 42.1 <5 ×  10−324 9.0 × 10−5

*This table only lists ICD-9 code 250.00, not the other diabetes codes that also appeared in this cohort of patients.