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. 2014 Feb 20;33(5):1055–1063. doi: 10.3892/ijmm.2014.1663

Figure 6.

Figure 6

Ex vivo optical imaging (OI) analysis of dissected organs. (A) Representative OI images of dissected organs of mice with acute kidney injury (AKI) and healthy mice treated with LCD- and DL-EVs sacrificed at 5 and 24 h after injection. (B) Fluorescence quantification of kidneys, expressed as the average radiance ± standard deviation (SD). ANOVA with Newman-Keuls multi-comparison test was performed. *p<0.05 AKI EVs vs. healthy EVs. (C) Fluorescence quantification, expressed as the average radiance ± SD, of lungs, liver and spleen. AKI mice treated with LCD-EVs sacrificed at 5 h (n=9) and at 24 h (n=7); AKI mice treated with DL-EVs sacrificed at 5 h (n=6) and at 24 h (n=5); healthy mice treated with LCD-EVs sacrificed at 5 h (n=6) and at 24 h (n=6); healthy mice treated with DL-EVs sacrificed at 5 h (n=3) and at 24 h (n=3). LCD-EV, labeled EVs produced by donor cells; DL-EV, directly labeled EVs.