Table 4. Genetic variants nominally significantly associated with colorectal-cancer risk identified from additional analyses by ethnic group in additive model.

						Number evaluated			Colorectal-cancer risk meta-analysis				Venice criteria garde^‡	False-positive report probability^§	Cumulative evidence of association

Genes	Variants	Alleles ^*	Chromosome	MAF (%)^†	Ethinicity	Studies	Cases	Controls	OR (95% CI)	P value	I² (%)	P_{heterogeneity}
CDH1	rs16260	A/C	16	28.02	White	6	6,761	6,646	0.93 (0.87-1.00)	0.048	23	0.26	AAC	0.642	Weak
MTRR	rs1801394	A/G	5	44.65	White	10	6,430	9,746	0.98 (0.93-1.02)	0.030	4	0.41	AAC	0.535	Weak
NQO1	rs1800566	T/C	16	17.88	White	8	6,293	6,566	1.09 (1.03-1.16)	0.006	0	0.50	AAC	0.183	Weak
OGG1	rs1052133	G/C	3	21.59	White	14	5,908	7,355	1.15 (1.01-1.32)	0.033	74	0.00	ACC	0.558	Weak
PTGS2	rs20417	C/G	1	2.76	Asian	4	1,285	3,040	1.44 (1.06-1.95)	0.019	28	0.25	BBC	0.420	Weak
NFKB1	rs28362491	–/ATTG	4	41.05	White	6	1,199	3,134	1.29 (1.11-1.50)	0.001	55	0.05	ACB	0.036	Weak
TCF7L2	rs7903146	T/C	10	29.08	White	3	1,960	14,290	1.12 (1.02-1.22)	0.015	0	0.47	AAC	0.335	Weak
TP53	rs1042522	C/G	17	37.15	Asian	8	3,993	4,943	1.14 (1.02-1.27)	0.021	60	0.02	ACC	0.430	Weak

Minor alleles/major alleles (Per Caucasian); majors alleles were treated as reference alleles in the analyses

Allelic ORs were estimated under the additive model. For dominant or recessive models, ORs were estimated for subjects who carry one or two minor alleles or subjects homozygous for the minor alleles,respectively.

^†

MAF=minor allele frequency in controls.

^‡

Venice criteria grades are for amount of evidence, replication of the association, and protection from bias.

^§

False-positive report probability (FPRP) was determined based on OR and P value of each variant from meta-analysis and a prior probability of 0.05.

Cumulative epidemiological evidence as graded by combination of results from Venice criteria and FPRP for association with colorectal-cancer risk.