Table 5. Additional genetic variants nominally significantly associated with colorectal-cancer risk in meta-analyses using dominant or recessive models.

						Number evaluated			Colorectal-cancer risk meta-analysis					Venice criteria grade^‡	False-positive report probability^§	Cumulative evidence of association

Genes	Variants	Alleles ^*	Chromosome	MAF (%)^†	Ethnicity	Studies	Cases	Controls	Genetic models	OR (95% CI)	P value	I² (%)	P_{heterogeneity}
SELS	rs34713741	T/C	15	33.22	All	3	1,442	2,071	Dominant	1.21 (1.05-1.39)	0.008	0	0.40	AAC	0.235	Weak
SERPINE1/PAI-1	rs1799889	5G/4G	7	44.94	White	4	2,241	4,534	Dominant	0.87 (0.78-0.97)	0.014	0	0.56	AAC	0.337	Weak
EPHX1	rs2234922	G/A	1	19.38	All	13	5,329	6,700	Dominant	0.91 (0.85-0.99)	0.020	0	0.50	AAC	0.46	Weak
ERCC5/XPG	rs17655	C/G	13	24.73	All	9	6,322	7,537	Dominant	1.13 (1.01-1.25)	0.027	38	0.12	ABC	0.48	Weak
RAD18	rs373572	C/T	3	29.22	All	3	3,174	3,397	Dominant	1.18 (1.01-1.37)	0.033	27	0.25	ABC	0.55	Weak
CCND1	rs9344	A/G	11	48.15	All	22	6,316	8,272	Dominant	1.13 (1.01-1.26)	0.035	43	0.00	ABC	0.569	Weak
IGF1	rs35767	T/C	12	24.75	All	3	2,717	4,880	Recessive	0.75 (0.62-0.91)	0.003	0	0.57	BAC	0.11	Weak
MGMT	rs12917	T/C	10	12.99	All	7	4,127	7,284	Recessive	1.54 (1.14-2.08)	0.005	0	0.47	BAA	0.158	Weak
CRP	rs1800947	C/G	1	5.70	All	4	2,916	3,544	Recessive	3.84 (1.38-10.74)	0.010	0	0.47	CAC	0.277	Weak
HPGD	rs2612656	G/A	4	22.75	White	3	2,979	5,575	Recessive	1.31 (1.05-1.64)	0.016	21	0.28	BAC	0.380	Weak
FRZB	rs7775	G/C	2	8.77	White	3	1,256	3,000	Recessive	3.20 (1.17-8.73)	0.023	64	0.06	CCC	0.468	Weak
TGFBR1	rs334354	A/G	9	26.71	All	4	1,226	2,776	Recessive	1.38 (1.04-1.84)	0.029	8	0.35	BAC	0.516	Weak
TGFB1	rs4803455	A/C	19	47.48	All	3	2,786	3,516	Recessive	1.14 (1.01-1.28)	0.030	0	0.37	AAC	0.536	Weak
LIPC	rs6083	A/G	15	36.52	All	3	4,702	4,914	Recessive	0.85 (0.74-0.99)	0.032	25	0.27	AAA	0.56	Weak
MTHFR	rs1801133	T/C	1	33.50	All	68	32,608	44,383	Recessive	0.92 (0.85-1)	0.036	52	0.00	ACC	0.61	Weak
CYP2C9	rs1799853	T/C	10	13.31	White	6	4,915	5,237	Recessive	1.36 (1.02-1.83)	0.038	0	0.76	BAA	0.60	Weak
MTRR	rs10380	T/C	5	9.31	White	4	3,869	5,141	Recessive	1.61 (1.02-2.52)	0.039	6	0.36	BAA	0.597	Weak

Minor alleles/Major alleles (Per Caucasian); majors alleles were treated as reference alleles in the analyses

Allelic ORs were estimated under the additive model. For dominant or recessive models, ORs were estimated for subjects who carry one or two minor alleles or subjects homozygous for the minor alleles, respectively.

^†

MAF=minor allele frequency in controls.

OR=odds ratio; CI=confidence interval.

^‡

Venice criteria grades are for amount of evidence, replication of the association, and protection from bias.

^§

False-positive report probability (FPRP) was determined based on OR and P value of each variant from meta-analysis and a prior probability of 0.05.

Cumulative epidemiological evidence as graded by combination of results from Venice criteria and FPRP for association with colorectal-cancer risk.