Table 6. Genetic variants showing no relation to colorectal-cancer risk in meta-analyses with at least 5,000 cases and 5,000 controls in additive model.

					Number assessed			Colorectal cancer risk		Heterogeneity

Genes	Variants	Comparisons^*	Frequency (%)^†	Ethnicity	Studies	Cases	Controls	OR (95% CI)	P value	I² (%)	P_{heterogeneity}
ABCB1	rs1202168	T vs C	41.25	White	4	6,318	5,805	1.05 (0.97-1.14)	0.191	55	0.08
ABCB1	rs9282564	G vs A	8.89	White	4	5,792	5,234	1.21 (0.78-1.88)	0.400	96	0.00
ABCB1/MDR1	rs1045642	C vs T	47.52	All	13	6,312	7,128	0.98 (0.89-1.07)	0.611	58	0.00
APC	rs459552	A vs T	22.27	All	8	6,654	7,117	0.96 (0.91-1.02)	0.205	0	0.66
CASP8	rs3834129	6 bp ins vs del	41.14	All	10	6,922	10,750	1.05 (0.92-1.20)	0.441	82	0.00
CASR	rs1042636	G vs A	8.52	White	4	6,298	7,839	1.00 (0.92-1.09)	0.936	0	0.66
CDH1	rs16260	A vs C	28.09	All	9	7,220	7,045	0.94 (0.88-1.01)	0.116	21	0.26
COMT	rs4680	A vs G	48.89	White	5	5,074	5,239	1.05 (0.94-1.16)	0.390	56	0.06
CYP1A1	rs4646903	C vs T	14.42	All	15	7,258	8,154	1.05 (0.92-1.19)	0.500	65	0.00
CYP1A2	rs762551	C vs A	30.45	All	11	7,667	8,242	1.02 (0.94-1.10)	0.664	55	0.01
CYP1B1	rs1056836	G vs C	43.27	White	9	8,709	9,097	1.02 (0.97-1.06)	0.488	0	0.44
CYP1B1	rs1800440	G vs A	18.36	White	6	6,679	6,923	0.97 (0.88-1.07)	0.580	53	0.06
CYP2C9	rs1057910	G vs A	7.16	All	8	8,538	9,182	1.00 (0.86-1.16)	0.994	62	0.01
EPHX1	rs1051740	C vs T	30.95	All	18	10,478	12,372	1.02 (0.97-1.08)	0.447	36	0.06
ERCC2/XPD	rs13181	C vs A	30.25	All	17	6,039	8,749	0.99 (0.92-1.05)	0.649	24	0.17
ERCC2/XPD	rs1799793	A vs G	29.71	All	7	5,470	7,135	1.01 (0.96-1.07)	0.674	0	0.68
GSTP1	rs1138272	T vs C	9.84	All	10	7,160	7,789	0.92 (0.80-1.06)	0.234	56	0.02
GSTP1	rs1695	G vs A	27.54	All	33	9,986	15,562	0.98 (0.93-1.03)	0.487	25	0.10
IGF1	(CA)n	non R19 vs R19	36.71	All	8	5,493	6,827	0.99 (0.89-1.09)	0.769	70	0.00
IGFBP3	rs2854744	C vs A	46.30	All	9	6,872	10,606	1.03 (0.98-1.07)	0.284	0	0.98
IL6	rs1800795	C vs G	38.55	All	14	6,952	8,657	1.01 (0.93-1.11)	0.749	65	0.00
IRS1	rs1801278	A vs G	6.92	White	7	7,048	7,533	1.08 (0.96-1.22)	0.219	39	0.13
MLH1	rs1799977	G vs A	29.56	All	10	6,384	8,972	1.01 (0.92-1.11)	0.904	58	0.01
MTHFD1	rs2236225	A vs G	45.19	White	6	6,535	9,347	0.98 (0.90-1.07)	0.603	67	0.01
MTHFR	rs1801131	C vs A	30.14	All	34	14,965	22,017	0.99 (0.94-1.03)	0.514	32	0.04
MTR	rs1805087	G vs A	19.42	All	19	12,945	17,655	0.99 (0.94-1.05)	0.717	33	0.09
MTRR	rs1801394	A vs G	48.33	All	16	7,674	11,593	0.96 (0.91-1.01)	0.110	37	0.12
MUTYH	rs3219484	A vs G	8.20	White	3	5,391	5,222	0.95 (0.68-1.34)	0.787	91	0.00
MUTYH	rs3219489	C vs G	28.44	All	4	5,082	5,280	1.09 (0.92-1.28)	0.317	81	0.00
NAT1	Phenotype	Fast vs slow	44.37	All	15	7,336	9,825	1.03 (0.92-1.16)	0.596	61	0.00
NQO1	rs1800566	T vs C	22.90	All	12	7,209	8,783	1.07 (0.99-1.15)	0.090	32	0.13
OGG1	rs1052133	G vs C	25.79	All	18	6,654	8,599	1.10 (0.99-1.23)	0.085	71	0.00
PPARG	rs1801282	G vs C	9.10	All	18	13,758	20,300	0.97 (0.91-1.03)	0.339	18	0.24
PPARG	rs3856806	T vs C	11.39	All	10	6,189	8,707	1.03 (0.96-1.11)	0.412	2	0.42
PTGS2/COX2	rs5275	C vs T	33.17	All	10	6,059	8,084	1.01 (0.97-1.07)	0.579	0	0.98
TGFBR1	rs11466445	9 bp del vs ins	9.19	All	10	6,338	6,689	1.04 (0.96-1.13)	0.379	1	0.43
TP53	rs1042522	C vs G	31.28	All	31	10,515	12,909	1.00 (0.92-1.10)	0.922	72	0.00
VDR	rs2228570	A vs G	37.32	All	20	13,631	15,155	1.00 (0.94-1.06)	0.959	53	0.00
VDR	rs7975232	A vs C	43.08	All	9	5,421	5,377	1.08 (0.98-1.19)	0.105	58	0.02
XRCC1	rs25487	G vs A	31.87	All	25	9,541	14,448	1.04 (0.97-1.11)	0.281	49	0.00

OR=odds ratio; CI=confidence interval.

Genetic comparison used in meta-analysis: Minor allele vs Major allele.

^†

Frequency of minor allele or effect genotype(s) in controls in primary meta-analysis