Table 3.

Summary of dose volume constraints for 3-fraction SABR regimen.

Organs at risk	Wulf et al. [15]	Hoyer et al. [24]	Timmerman [30]	Rusthoven et al. [25]	QUANTEC [31]
Liver	D 30% < 21 Gy D 50% < 15 Gy	700 mL < 15 Gy	700 mL < 17 Gy	700 mL < 15 Gy	700 mL ≤ 15 Gy D mean < 15 Gy
Esophagus	D 5 mL < 21 Gy	D 1 mL < 21 Gy	D 5 mL < 21 Gy, D max⁡ < 27 Gy	NA	NA
Stomach	D 5 mL < 21 Gy	D 1 mL < 21 Gy	D 10 mL < 21 Gy D max⁡ < 24 Gy	D max⁡ ≤ 30 Gy	D max⁡ < 30 Gy
Bowel	D 5 mL < 21 Gy	D 1 mL < 21 Gy	D 5 mL < 16 Gy D max⁡ < 24 Gy	D max⁡ ≤ 30 Gy	D max⁡ < 30 Gy
Kidney	NA	Total kidney D 35% < 15 Gy	Total kidney 200 mL < 14.4 Gy	Total kidney D 35% < 15 Gy	NA
Spinal cord	NA	D max⁡ < 18 Gy	D 0.25 mL < 18 Gy D max⁡ < 22 Gy	D max⁡ ≤ 18 Gy	D max⁡ ≤ 20 Gy
Heart	D 5 mL < 21 Gy	D 1 mL < 30 Gy	D 15 mL < 24 Gy D max⁡ < 30 Gy	NA	NA

SABR: stereotactic ablative radiotherapy; QUANTEC: Quantitative Analyses of Normal Tissue Effects in the Clinic; NA: not available; D _x%: dose to x%; D _x mL: dose to x mL; D _max⁡: maximum point dose; D _mean: mean dose.