Table 7.
Effect of aqueous extract of Trigonella foenum-graecum (AqE-TFG) on serum leptin, glucose, insulin, HOMA-IR, QUICKI, apo-B, and adiponectin levels in high fat diet- (HFD-) induced obese rats.
| Groups | Leptin (ng/mL) | Glucose (mg/dL) | Insulin (μU/mL) | HOMA-IR | QUICKI | Apo-B (mg/dL) | Adiponectin (ng/mL) |
|---|---|---|---|---|---|---|---|
| Normal control | 2.49 ± 0.11 | 103.16 ± 2.78 | 45.08 ± 3.10 | 1.90 ± 0.12 | 0.274 ± 0.002 | 2.16 ± 0.19 | 6421.67 ± 2.25 |
| HFD control | 8.62 ± 0.40## | 152.83 ± 5.22## | 87.61 ± 6.13## | 5.54 ± 0.48## | 0.243 ± 0.002## | 7.34 ± 0.48## | 6378.49 ± 3.86## |
| HFD + AqE-TFG (0.5 g/kg) | 5.87 ± 0.31** | 135.66 ± 3.39* | 65.42 ± 3.90** | 3.67 ± 0.26** | 0.254 ± 0.002* | 3.80 ± 0.27** | 6398.37 ± 4.40** |
| HFD + AqE-TFG (1 g/kg) | 4.23 ± 0.26** | 122.17 ± 3.84** | 54.13 ± 4.36** | 2.74 ± 0.23** | 0.262 ± 0.004** | 3.03 ± 0.21** | 6409.65 ± 1.98** |
| HFD + orlistat (10 mg/kg) | 3.58 ± 0.19** | 128.03 ± 4.60** | 48.33 ± 2.95** | 2.57 ± 0.21** | 0.265 ± 0.003** | 2.68 ± 0.33** | 6413.27 ± 3.52** |
Results are expressed as mean ± S.E.M. (n = 10); ## P < 0.01 compared to normal control; *P < 0.05 and **P < 0.01 compared to HFD control.