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Representative conformations illustrating residue separation in the closed (bottom), semiopen (middle), and wide-open states (top). The first column perspective is head-on, the second angled and the third perpendicular with respect to the flap. Blue residues depict the ILEα328/ALAβ170 separation, yellow shows HISα322/GLYα47, and silver shows GLUα330/ALAβ173.
