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Targeted mutation of Tsc1 in bone marrow cells resulted in transient increase but long-term reduction in HSC self-renewal. A. The diagram of experimental design. B. BrdU incorporation of HSCs from WT- or KO- donors after 24h labeling. n=4. C. HSC numbers derived from WT- or KO- donors in the recipients after pIpC treatment. n=4.
