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. Author manuscript; available in PMC: 2014 May 14.
Published in final edited form as: Chem Biol. 2007 May;14(5):565–576. doi: 10.1016/j.chembiol.2007.04.006

Figure 3.

Figure 3

Biosynthetic pathway of aeruginosides 126A and 126B.A) Schematic representation of the aeruginoside biosynthesis gene cluster of Planktothrix agardhii CYA126/8. Genes encoding NRPS or NRPS/PKS hybrid components are indicated in light and dark grey, respectively. Genes presumably involved in Choi biosynthesis are checkered and tailoring genes are highlighted with stripes. Genes that were not associated with aeruginoside biosynthesis are shown in white.

B) Model for the formation of aeruginoside A and B and predicted domains of AerA-AerI. Each circle represents a NRPS domain or tailoring function. A, adenylation domain; KR, ketoreductase domain; ACP, acyl carrier protein; C, condensation domain; PCP, peptidyl carrier protein; E, epimerization domain.