Skip to main content
. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: Curr Opin Cell Biol. 2013 Dec 7;27:44–50. doi: 10.1016/j.ceb.2013.11.004

Figure 1. Ubiquitin- and ESCRT-dependent sorting of CXCR4.

Figure 1

In the absence of agonist, CXCR4 resides at the plasma membrane (PM). After agonist stimulation, CXCR4 is ubiquitinated by the NEDD4-family member AIP4 E3 ubiquitin ligase and sorted from early endosomes (EE) to late endosomes (LE)/multivesicular bodies (MVBs) by the ESCRT machinery, which binds to CXCR4 via ubiquitin-binding domains (UBDs) and function sequentially to sort ubiquitinated CXCR4 to intralumenal vesicles (ILVs) of MVBs for degradation. The AAA-ATPase Vps4 disassembles and recycles ESCRT-III and is essential for ESCRT function and CXCR4 degradation.