Skip to main content
. 2011 Sep 20;3(2):132–137. doi: 10.1111/j.2040-1124.2011.00160.x

Figure 1.

image

 Effect of FTY720 alone or in combination with insulin glargine on survival rates of NOD mice with overt type 1 diabetes mellitus (DM). Female NOD mice with hyperglycemia (i.e. with overt DM) were treated with: 0.1 mg/kg, p.o., FTY720 twice a week (n = 11; ○); 1.0 IU, s.c., insulin glargine once daily, (n = 13; □); 0.1 mg/kg, p.o., FTY720 twice a week plus insulin glargine (for dosing, refer to Materials and Methods; n = 13; •); or vehicle (n = 11; △). Survival was monitored for 70 days after start of treatment. The significance of differences in survival was evaluated using the log rank test.