Table 2. Genes in the Trypanosoma cruzi sterol biosynthesis pathway.
| SBP Ortholog | T. cruzi Locus Identifiers(s) | Current annotation | Ortholog Group | In KEGG? | Gene Name |
| ERG10 | TcCLB.511003.60 | Hypothetical protein | OG4_10214 | Yes | TcACAT |
| ERG13 | TcCLB.511903.40, TcCLB.511071.50 | Hypothetical protein, conserved | OG4_11016 | No | TcHMGS |
| HMG1, HMG2 | TcCLB.509167.20, TcCLB.506831.40 | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | OG4_11458 | Yes | TcHMGR |
| ERG12 | TcCLB.436521.9, TcCLB.509237.10 | Mevalonate kinase, putative | OG4_11698 | Yes | TcMK |
| ERG8 | TcCLB.508277.140, TcCLB.507913.20 | Phosphomevalonate kinase e-like protein, putative | OG4_15366 | Yes | TcPMK |
| ERG19 | TcCLB.507993.330, TcCLB.511281.40 | Diphosphomevalonate decarboxylase, putative | OG4_11688 | Yes | TcMVD |
| ERG20 | TcCLB.511823.70, TcCLB.508323.9 | Farnesyl pyrophosphate synthase, putative | OG4_11009 | Yes | TcFPPS |
| IDI1 | TcCLB.408799.19, TcCLB.510431.10 | Isopentenyl-diphosphate delta-isomerase, putative | OG4_14499 | Yes 6 | TcIDI |
| ERG9 | TcCLB.507897.20, TcCLB.508369.20 | Farnesyl transferase, putative; squalene synthase, putative | OG4_13084 | Yes | TcSQS |
| ERG1 | TcCLB.509589.20, TcCLB.503999.10 | Squalene monooxigenase, putative | OG4_13490 | Yes | TcSQLE |
| ERG7 | TcCLB.508175.70, TcCLB.506825.170 | Lanosterol synthase, putative | OG4_11381 | No | TcOSC |
| ERG11 | TcCLB.506297.260, TcCLB.510101.50 | Lanosterol 14-α-demethylase, putative | OG4_12975 | Yes | Tc14DM, cCYP51 |
| ERG24 | TcCLB.507969.60, TcCLB.507129.30 | C-14 sterol reductase, putative | OG4_12018 | Yes | Tc14SR |
| – | TcCLB.511339.20, TcCLB.511895.69, TcCLB.509235.20 | C-5 sterol desaturase, putative | OG4_20087 | No | TcSMO-like |
| ERG26 | TcCLB.510873.10 | NAD(P)-dependent steroid dehydrogenase protein, putative | OG4_12533 | No | TcNDSDHL |
| ERG27 | – | – | – | No | – |
| ERG6 | TcCLB.504191.10, TcCLB.505683.10, TcCLB.510185.10 | Sterol 24-C-methyltransferase, putative | OG4_13307 | Yes | Tc24SMT |
| ERG2 | TcCLB.510329.90 | C-8 sterol isomerase, putative | OG4_14573 | Yes | Tc8SI |
| ERG3 | TcCLB.473111.10, TcCLB.507853.10 | Lathosterol oxidase, putative | OG4_12421 | No | TcSC5D |
| ERG5 | TcCLB.506945.190 | Cytochrome p450-like protein, putative | OG4_14688 | No | TcSC22D |
| ERG4 | TcCLB.506577.120, TcCLB.507709.90 | Sterol C-24 reductase, putative | OG4_16908 | Yes | TcSC24R |
The table lists T. cruzi genes mapped to either the corresponding KEGG maps, or the yeast SBPs (see Table 1). OrthoMCL identifiers are from the OrthoMCL Database version 4. T. cruzi gene identifiers are those currently available at the TriTrypDB resource. The fifth column shows whether the gene was mapped to the corresponding KEGG metabolic map at the time of this writing. The last column shows the nomenclature used in this work. Some of these gene names were previously used in the literature, and others are used here for the first time, based on the gene names of relevant orthologs. In the case of the TcIDI gene, the two listed alleles are truncated copies of the gene. The full-length gene is deposited in GenBank as AJ866772. While in the case of the TcNSDHL gene, the copy annotated by the genome project is truncated due to genome assembly problems. The full-length gene is deposited in GenBank as JN050853 (this work).