Table 4. Comparative analysis of the genetic diversity present in the sterol biosynthesis pathway of different kinetoplastids.
dN/dS (ω) | |||
Yeast gene, Std symbol | Af Tryps | Leish | Tcr |
ERG10/ACAT | – | – | 0.028 |
ERG13/HMGS | 0.057 | 0.048 | 0.054 |
HMG1/HMGR | 0.065 | 0.052 | 0.057 |
ERG12/MK | 0.077 | 0.076 | 0.077 |
ERG8/PMK | 0.110† | 0.122† | 0.122† |
ERG19/MVD | 0.067 | 0.072 | 0.059 |
IDI1/IDI | 0.051* | 0.043* | 0.048* |
ERG20/FPPS | 0.060 | 0.061 | 0.065 |
ERG9/FDFT, SQS | 0.085 | 0.087 | 0.093 |
ERG1/SQLE | 0.115† | 0.107† | 0.115† |
ERG7/LSS, OSC | 0.109† | 0.113† | 0.113† |
ERG11/14DM, CYP51 | 0.042* | 0.040* | 0.039* |
ERG24/14SR, TM7SF2 | 0.142† | 0.109† | 0.110† |
ERG25/SMO/SC4MOL | – | 0.271 | – |
–/SMO-like | 0.080 | 0.082 | 0.092 |
ERG26/NSDHL | 0.051* | 0.057 | 0.058 |
ERG27/3KSR | – | – | – |
ERG6/24SMT | 0.065 | 0.062 | 0.070 |
ERG2/8SI | 0.115† | 0.100 | 0.097 |
ERG3/SC5D | 0.069 | 0.059 | 0.060 |
ERG5/SC22D | – | 0.028* | 0.107† |
ERG4/SC24R | – | 0.097 | 0.070 |
Average | 0.080 | 0.075 | 0.079 |
Standard deviation | 0.028 | 0.028 | 0.026 |
The table shows the dN/dS (ω) ratio observed in the african trypanosome lineage (Af Tryps) (T. brucei brucei, T. brucei gambiense, T. evansi, T. congolense, T. vivax), in the Leishmania lineage (Leish) (L. major, L. infantum, L. braziliensis, and L. mexicana), and in the T. cruzi lineage (Tcr, sequences from TcI{TcVI DTUs). The values that are above (†) or under (*) a standard deviation from the average of each column are marked.