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. 2014 May 14;9(5):e97271. doi: 10.1371/journal.pone.0097271

Figure 11. The insertion rate of VEGFR1 tunes the anti-angiogenic effect of anti-VEGF treatment.

Figure 11

Sensitivity analysis of the insertion rate of VEGFR1 into the tEC membrane tunes the efficacy of anti-VEGF treatment. This example examines “Density 2” at 3 weeks of tumor growth giving 69,500 VEGFR1/tEC. The insertion rate using 69,500 VEGFR1/tEC is approximately 1e-14 s−1, where anti-VEGF treatment provides a pro-angiogenic response. Decreasing the insertion rate allows for anti-VEGF treatment to provide an anti-angiogenic response.