. 2014 May 14;9(5):e96901. doi: 10.1371/journal.pone.0096901

Table 3. Top twenty significantly expressed genes (FDR<0.05, Limma) ranked by fold change.

Gene	Fold change (Log2)	Fold change	Preterm birth within 48 hours Median expression (25^th, 75^th percentile)	No preterm birth within 48 hours Median expression (25^th, 75^th percentile)	FDR	Gene annotation
Up-regulated genes (n = 12)
ZDHHC19	1.202	2.30	4.66 (3.95, 5.51)	3.47 (3.19, 4.21)	0.000	zinc finger, DHHC-type containing 19
HPGD	1.049	2.07	5.80 (5.11, 7.60)	5.08 (4.17, 6.95)	0.047	hydroxyprostaglandin dehydrogenase 15-(NAD)
GPR84	0.990	1.99	8.00 (6.77, 8.78)	6.78 (6.40, 7.64)	0.007	G protein-coupled receptor 84
OPLAH	0.934	1.91	6.62 (5.89, 7.90)	5.82 (5.26, 6.69)	0.003	5-oxoprolinase (ATP-hydrolysing)
TDRD9	0.906	1.87	4.86 (3.68, 6.08)	3.89 (3.24, 4.94)	0.018	tudor domain containing 9
ATP9A	0.880	1.84	7.86 (6.73, 8.92)	6.71 (6.15, 7.78)	0.013	ATPase, class II, type 9A
GALNT14	0.879	1.84	9.04 (8.46, 9.58)	8.27 (7.86, 8.66)	0.000	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acety lgalactosaminyltransferase 14
SLC26A8	0.802	1.74	7.53 (6.71, 8.08)	6.76 (6.05, 7.48)	0.015	solute carrier family 26, member 8
CDK5RAP2	0.768	1.70	8.73 (7.73, 10.10)	8.12 (7.44, 8.80)	0.017	CDK5 regulatory subunit associated protein 2
ST3GAL4-AS1	0.760	1.69	9.15 (8.41, 9.81)	8.41 (7.71, 9.03)	0.015	ST3GAL4 antisense RNA 1 (head to head)
G0S2	0.758	1.69	7.56 (7.10, 8.05)	6.83 (6.26, 7.53)	0.006	G0/G1switch 2
SOCS3	0.757	1.69	8.45 (7.51, 9.13)	7.77 (7.14, 8.22)	0.003	suppressor of cytokine signaling 3
Down-regulated genes (n = 8)
METTL18	−0.909	0.53	3.46 (2.73, 3.79)	4.20 (3.52, 5.00)	0.002	methyltransferase like 18
GOLGA8A	−0.874	0.55	8.48 (7.63, 9.36)	9.32 (8.40, 10.26)	0.037	golgin A8 family, member A
ZNF302	−0.802	0.57	3.20 (2.76, 3.53)	3.51 (3.12, 4.37)	0.007	zinc finger protein 302
TRMT13	−0.797	0.58	4.10 (3.53, 5.12)	5.19 (3.74, 6.15)	0.047	tRNA methyltransferase 13 homolog (S. cerevisiae)
CETN3	−0.773	0.59	4.20 (3.01, 4.36)	4.41 (3.98, 5.70)	0.032	centrin, EF-hand protein, 3
ZFAND1	−0.771	0.59	5.35 (4.68, 6.31)	6.18 (5.12, 6.99)	0.040	zinc finger, AN1-type domain 1
STAP1	−0.764	0.59	4.10 (3.52, 4.52)	4.78 (4.09, 5.50)	0.007	signal transducing adaptor family member 1
MS4A1	−0.758	0.59	6.93 (6.09, 7.55)	7.76 (6.97, 8.69)	0.028	membrane-spanning 4-domains, subfamily A, member 1