Table 3. Kidney function.
| Group | Baseline | 30 h | P1 | P2 | P3 (P adj) | |
| pH | Control | 7.43; 7.42–7.54 | 7.46; 7.38–7.55 | 1.00 | Ref. | |
| LPS-only | 7.46; 7.45–7.52 | 7.30; 7.25–7.32 | 0.06 | 0.004 | ||
| LPS + iNO | 7.46; 7.39–7.54 | 7.34; 7.21–7.42 | 0.03 | 0.33 (0.61) | ||
| LPS + IV steroid | 7.47; 7.33–7.52 | 7.33; 7.17–7.40 | 0.03 | 0.31 (0.61) | ||
| LPS + iNO + IV steroid | 7.47; 7.40–7.50 | 7.41; 7.27–7.54 | 0.56 | 0.18 (0.54) | ||
| BE (mEq/L) | Control | +6.0; +1.0–+8.0 | +1.5; −9.0–+7.0 | 0.06 | Ref. | |
| LPS-only | +6.0; +4.0–+8.0 | −8.0; −8.0–−5.0 | 0.06 | 0.004 | ||
| LPS + iNO | +6.5; +2.0–+9.0 | −6.5; −11.0–+4.0 | 0.03 | 0.83 (0.83) | ||
| LPS + IV steroid | +4.0; +3.0–+7.0 | −6.0; −9.0–+1.0 | 0.03 | 0.017(0.045) | ||
| LPS + iNO + IV steroid | +4.0; +0.0–+6.0 | −0.5; −6.0–+8.0 | 0.31 | 0.015(0.045) | ||
| Urea (mmol/L) | Control | 4.67; 2.17–5.33 | 2.34; 1.67–3.00 | 0.03 | Ref. | |
| LPS-only | 4.34; 3.50–6.67 | 11.00; 2.33–17.67 | 0.31 | 0.02 | ||
| LPS + iNO | 3.83; 3.50–6.33 | 8.92; 5.83–16.17 | 0.03 | 0.93 (1.0) | ||
| LPS + IV steroid | 3.67; 1.50–6.33 | 9.67; 4.83–27.17 | 0.03 | 0.93 (1.0) | ||
| LPS + iNO + IV steroid | 3.75; 2.33–7.60 | 8.17; 3.33–13.67 | 0.22 | 0.79 (1.0) | ||
| Urine output 12–30 hours, (mL) | Control | 1040; 200–1500 | Ref. | |||
| LPS-only | 580; 400–1160 | 0.58 | ||||
| LPS + iNO | 1058; 0–1790 | 0.66 (1.0) | ||||
| LPS + IV steroid | 716; 150–2095 | 0.47 (1.0) | ||||
| LPS + iNO + IV steroid | 1025; 400–2500 | 0.26 (0.79) | ||||
Statistics: Values are shown as median and range.
1
Within group from baseline to 30 hours (urine output: no baseline value, volume collected over time, from 12 to 30 hours).
2
Comparison of distribution of differences between LPS-only and control.
3
Comparison of distribution of differences versus LPS-only (Bonferroni-Holm adjusted p-values within parenthesis).