Table 4. Meta-analysis for the association of rs1883832 with coronary artery disease.
Genetic model | OR 95%CI | P | P heterogeneity | I2 |
C/C versus T/T | Crude OR1: 2.869 (2.197, 3.746) | <0.001 | 0.444 | 0% |
Modified OR1: 2.866 (2.203, 3.729) | <0.001 | – | – | |
C/T versus T/T | Crude OR2: 1.691 (1.359, 2.105) | <0.001 | 0.838 | 0% |
Modified OR2: 1.680 (1.352, 2.086) | <0.001 | – | – | |
C/C versus C/T | Crude OR3: 1.688 (1.352, 2.109) | <0.001 | 0.684 | 0% |
Modified OR3: 1.707 (1.366, 2.132) | <0.001 | – | – | |
Dominant model (C/C and C/T) versus T/T | OR4: 1.965 (1.594, 2.423) | <0.001 | 0.58 | 0% |
Recessive model C/C versus (C/T and T/T) | OR5: 1.971 (1.594, 2.438) | <0.001 | 0.603 | 0% |
Additive model | OR6: 1.689 (1.480, 1.927) | <0.001 | 0.403 | 0.6% |
Included publications: Li Y, 2007; Wang CP, 2009; Tian CX, 2010; Yan JC, 2010; Wang M, 2011.
Likelihood ratio test: LR = 63.73, P<0.001.
Pooled C allele frequency: 45.1% (42.7%–47.4%), P heterogeneity = 0.156, I2 = 39.7%.
Abbreviation: ACS, acute coronary syndrome; CAD coronary artery disease; IS, ischemic stroke; CI, cerebral infarction;
OR, odds ratio; 95% CI, 95% confidence interval.