Table 2. BMI Profiles of Participants with Different FTO rs9939609 Genotypes and Cross-sectional Associations between FTO and BMI by Sex and Age.
| Sex | Age (years) | n | BMI, kg/m2, Mean (SD) | P for Trend | Difference in BMI per A allelea | |||
| (TT/TA/AA) | TT | TA | AA | β | 95%CI | |||
| All | 6–8 | 440/109/8 | 18.7 (4.0) | 18.7 (4.3) | 19.9 (3.5) | 0.79 | 0.1 | −0.61, 0.81 |
| 9–11 | 807/235/21 | 21.1 (4.4) | 21.7 (4.3) | 21.5 (4.7) | 0.078 | 0.48 | −0.05, 1.01 | |
| 12–14 | 826/215/18 | 22.4 (5.0) | 23.6 (4.7) | 24.7 (6.0) | <0.001 | 1.2 | 0.57, 1.84 | |
| 15–18 | 645/165/14 | 23.7 (4.9) | 24.8 (4.6) | 25.3 (4.9) | 0.002 | 1.07 | 0.39, 1.75 | |
| All | 2718/724/61 | 21.7 (4.9) | 22.5 (4.9) | 23.0 (5.3) | <0.001 | 0.79 | 0.47, 1.10 | |
| Boys | 6–8 | 227/65/6 | 19.2 (4.2) | 19.9 (4.5) | 20.7 (3.8) | 0.153 | 0.74 | −0.27, 1.75 |
| 9–11 | 445/123/12 | 21.9 (4.6) | 22.2 (4.5) | 23.8 (3.5) | 0.167 | 0.54 | −0.23, 1.31 | |
| 12–14 | 400/105/6 | 23.3 (5.3) | 24.1 (4.7) | 31.2 (3.2) | 0.004 | 1.5 | 0.49, 2.51 | |
| 15–18 | 308/75/9 | 25.5 (5.1) | 25.8 (4.7) | 24.9 (4.3) | 0.847 | 0.1 | −0.93, 1.14 | |
| All | 1380/368/33 | 22.6 (5.2) | 23.2 (5.0) | 24.9 (4.9) | 0.003 | 0.71 | 0.24, 1.18 | |
| Girls | 6–8 | 213/44/2 | 18.1 (3.6) | 16.9 (3.1) | 17.5 (1.2) | 0.063 | −1 | −2.05, 0.06 |
| 9–11 | 362/112/9 | 20.2 (4.1) | 21.1 (3.9) | 18.4 (4.5) | 0.299 | 0.4 | −0.35, 1.15 | |
| 12–14 | 426/110/12 | 21.6 (4.6) | 23.1 (4.6) | 21.4 (4.1) | 0.018 | 0.97 | 0.17, 1.77 | |
| 15–18 | 337/90/5 | 22.0 (4.4) | 24.1 (4.4) | 26.1 (6.3) | <0.001 | 2.02 | 1.13, 2.91 | |
| All | 1338/356/28 | 20.8 (4.4) | 21.9 (4.7) | 21.0 (5.2) | <0.001 | 0.88 | 0.45, 1.30 | |
Abbreviations: BMI, body mass index; CI, confidence interval; FTO, fat mass- and obesity-associated gene.
a
Linear regression model was used to estimate the difference in BMI per A allele and 95% CI adjusted for sex and age.