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. 2014 May 14;9(5):e97519. doi: 10.1371/journal.pone.0097519

Figure 1. Top. Structure of CSF-1R cytoplasmic region.

Figure 1

Crystallographic structures of the native receptor (A) in the inactive (2OGV[22]) and (B) the active forms (3LCD [85] are presented as cartoon. The different domains of CSF-1R and key structural fragments are highlighted in color. The N-terminal proximal lobe (N-lobe) is in blue, the C-terminal distal lobe (C-lobe) is in green, the Cα-helix is in cyan, the activation loop (A-loop) is in red, the juxtamembrane region (JMR) is in orange. The DFG motif (Asp796, Phe797, Gly798) and position of D802V mutation (insert) are represented in sticks. Bottom. The JMR sequence in RTKs of III family. The sequence alignment shows a poor sequence conversation of the JMR among the receptors TK of type III. Identical residues and similar residues are shown in red and in green, respectively. The three strongly conserved tyrosine residues are contoured. Except CSF-1R, the other RTKs from III family possess a second functional phosphotyrosine (green, contoured) in JM-Switch.