Figure 3. Reaction scheme for the synthesis of DOX-hyd-PEG-FA conjugate.
(1) NHS, DCC, DMSO; (2) H2N-PEG-COOH, TEA, DMSO; (3) NHS, DCC, BOCNHNH2, DMSO, TEA; (4) TFA, DMSO; (5) DOX, TFA, DMSO.
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