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. 2014 May 14;9(5):e97358. doi: 10.1371/journal.pone.0097358

Figure 13. In vivo antitumor activity of DOX-hyd-PEG-FA NPs.

Figure 13

Athymic nude mice xenografted with KB cells were intravenously injected with different doses of DOX-hyd-PEG-FA NPs (2.5, 5 and 10 mg/kg equivalent DOX) and one dose of DOX (5 mg/kg) every 7 day (days 1, 7, and 14). Panel A-tumor volume changes of tumor bearing mice, *P<0.05 vs free DOX, #P<0.05 vs 5 mg/kg DOX-hyd-PEG-FA NPs, n = 3. Panel B-body weight changes in tumor bearing nude mice, *P<0.05 vs free DOX, n = 3. Panel C-survival curve of tumor bearing mice. *P<0.05 vs free DOX, n = 3.