Table 2. Cytotoxicity for A549 cells, KB cells and HepG2 cells treated with DOX, DOX-hyd-PEG-FA NPs, DOX-hyd-PEG NPs, DOX-ami-PEG-FA NPsz and DOX-ami-PEG NPs.
| Drugs | IC50 (µmol/L) | ||
| A549 cells | KB cells | HepG2 cells | |
| DOX | 3.3±0.8 | 2.2±0.6 | 2.9±0.4 |
| DOX-hyd-PEG-FA NPs | 2.7±0.4* | 0.8±0.2** ## $$ | 1.5±0.3* # $ |
| DOX-hyd-PEG NPs | 3.2±0.7 | 2.8 ±0.3 | 3.1±0.6 |
| DOX-ami-PEG-FA NPs | 4.9±1.1 | 3.3±0.9 | 3.8±1.3 |
| DOX-ami-PEG NPs | 4.7±0.9 | 4.0±1.2 | 4.3±0.8 |
*p<0.05,
**p<0.01 vs DOX-ami-PEG-FA NPs.
#
p<0.05,
##
p<0.01 vs DOX-hyd-PEG NPs.
$
p<0.05,
$$
p<0.01 vs DOX.