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. 2014 May 14;9(5):e97603. doi: 10.1371/journal.pone.0097603

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© 2014 Klomp et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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An example of doublecortin (DCX) expression along the subgranular zone is shown for adult-treated (A) and adolescent-treated rats (B). C) Two-Way ANOVA revealed both a significant age-by-treatment interaction effect (p = 0.036) and a significant effect of age (p < 0.001) on the expression of DCX+ cells. D) There were regional differences in the amount of DCX+ cells. There was a significant effect of age in all sub-regions (p < 0.001), a significant treatment effect in the ventral infrapyramidal blade of the dentate gyrus (p = 0.021), and a significant age-by-treatment interaction effect in the dorsal infrapyramidal blade (p = 0.028). E) There was both a significant effect of age (p = 0.017) as well as a main effect of treatment (p = 0.045) on dentate gyrus volume. Dentate gyrus volume comprised the SGZ plus GCL. * = main effect of age; = main effect of treatment; # = age-by-treatment effect. P-values below 0.050 were considered statistically significant. Error bars indicate ± 1 S.E.M.

Inline graphic — An example of doublecortin (DCX) expression along the subgranular zone is shown for adult-treated (A) and adolescent-treated rats (B). C) Two-Way ANOVA revealed both a significant age-by-treatment interaction effect (p = 0.036) and a significant effect of age (p < 0.001) on the expression of DCX+ cells. D) There were regional differences in the amount of DCX+ cells. There was a significant effect of age in all sub-regions (p < 0.001), a significant treatment effect in the ventral infrapyramidal blade of the dentate gyrus (p = 0.021), and a significant age-by-treatment interaction effect in the dorsal infrapyramidal blade (p = 0.028). E) There was both a significant effect of age (p = 0.017) as well as a main effect of treatment (p = 0.045) on dentate gyrus volume. Dentate gyrus volume comprised the SGZ plus GCL. * = main effect of age; = main effect of treatment; # = age-by-treatment effect. P-values below 0.050 were considered statistically significant. Error bars indicate ± 1 S.E.M.