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Mechanism of bone-targeting system.
Notes: Negatively-charged AAA-tagged enzyme will circulate in blood for longer time and (1) will be delivered to bone more efficiently, (2) will bind with calcium sites on HA, (3) will be released from HA by proteolytic process, and (4) will be taken up by the receptor-mediated pathways.
Abbreviations: AAA, triple adenine; HA, hydroxyapatite.
