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. 2014 May 8;9:2191–2204. doi: 10.2147/IJN.S58397

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© 2014 Di Bucchianico et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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FISH analysis in PBL and Raw264.7 after exposure to 5 nm and 15 nm Au NPs.

Notes: Using pancentromeric probes applied to the CBMN Cyt slides, the centromeric spots were analyzed and the exposure of Raw264.7 to 15 nm Au NPs showed dose-dependent (P=0.01) aneuploidogenic events. Data are shown as mean ± SEM (PBL: n=4; Raw264.7: n=6). Student’s t-test: *P<0.05; **P<0.01; ***P<0.001.

Abbreviations: Au NP, gold nanoparticle; C+, positive control (MMC 0.1 μg/mL); C−, negative (untreated) control; CBMN Cyt, cytokinesis-block micronucleus cytome; FISH, fluorescence in situ hybridization; h, hours; MN C+, micronuclei centromere +ve; MN C−, micronuclei centromere -ve; PBL, peripheral blood lymphocytes; SEM, standard error of the mean.