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Effect of metformin on cisplatin and mitomycin C cytotoxicity for OSCC cells. OSCC cells, untreated or treated with 10 mM metformin for 24 hours and then treated with (A) cisplatin or (B) mitomycin C for a further 48 hours, were assessed by MTT assay. All metformin-cisplatin treated cells displayed a trend for higher LD50 values, with WHCO1 and SNO cells statistically higher (n = 3, mean ± SD).
