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Increased intracellular thiols causes cisplatin resistance in OSCC cells. The cell permeable thiol derivative NAC was used to confirm the role of thiols in cisplatin resistance in OSCC cells. Cells were either untreated or treated with 10 mM NAC for 24 hours and then treated with a concentration range of cisplatin for a further 48. Cytotoxicity was assessed by MTT assay. All NAC-cisplatin treated cells displayed higher LD50 values than cisplatin treated cells alone (n = 3, mean ± SD).
