Table 1.
Baseline Characteristics of the Study Participants by Cognitive Status
| Baseline Variables | MCI (n=370) | Normal cognition (n=1055) | P Value |
|---|---|---|---|
| Male sex, N (%) | 186 (50.27) | 529 (50.14) | .9662 |
| Age (years) -- median (IQR) | 82.08 (77.42, 85.16) | 78.33 (74.37, 82.73) | <.0001 |
| Education (years) -- median (IQR) | 12 (12, 15) | 13 (12, 16) | <.0001 |
| APOE E4 allele (E24/34/44 vs. 22/23/33), N (%)a | 109 (29.54) | 239 (22.78) | .0095 |
| Hypertension, N (%) | 290 (78.38) | 794 (75.26) | .2265 |
| Stroke, N (%) | 48 (12.97) | 87 (8.25) | .0076 |
| BDI-II Depression (≥13), N (%)b | 42(11.80) | 65 (6.38) | .0010 |
| BMI, median (IQR)c | 27.27 (24.04, 30.23) | 27.20 (24.49, 30.34) | .5075 |
| Smokers | .8700 | ||
| Never | 193 (52.16) | 539 (51.09) | |
| Former | 162 (43.78) | 477 (45.21) | |
| Current | 15 (4.05) | 39 (3.70) | |
| Coronary artery disease, N (%) | 161 (43.51) | 415 (39.34) | .1589 |
| Diabetes Mellitus, N (%) | 78 (21.08) | 165 (15.64) | .0166 |
| COPD, N (%) | 52 (14.05) | 119(11.28) | .1576 |
| Memory z score – median (IQR) | −0.28 (−0.83, 0.26) | 0.45 (−0.14, 1.03) | <.0001 |
| Language z score – median (IQR) | −0.23 (−0.90, 0.35) | 0.37 (−0.18, 0.93) | <.0001 |
| Attention z score – median (IQR) | −0.22 (−0.83, 0.37) | 0.46 (−0.10, 0.94) | <.0001 |
| Visual Spatial z score – median (IQR) | −0.18 (−0.90, 0.38) | 0.38 (−0.24, 0.92) | <.0001 |
| Global z score – median (IQR) | −0.38 (−0.87, 0.16) | 0.51 (−0.04, 1.01) | <.0001 |
Notes: Data are n (%) or median (IQR). Abbreviations: IQR, interquartile ratio; BMI, body mass index; BDI, Beck Depression Inventory; COPD, chronic obstructive pulmonary disease; MI, myocardial infarction.
a
7 patients missing APOE status (6 Normal, 1 MCI), percentage was based on non-missing data.
b
50 patients missing BMI (36 Normal, 14 MCI), percentage was based on non-missing data.
c
26 patients missing BDI-II Depression (18 Normal, 8 MCI), percentage was based on non-missing data.