Table 2. Databases used for drug-repositioning studies.

Fields	Databases[LM6]	Website[LM7]	Refs
Chemical structure	PubChem	http://pubchem.ncbi.nlm.nih.gov
	Collaborative Drug Discovery Vault	https://www.collaborativedrug.com
	Drugbank		[51]
	TTD		[52]
	PharmGKB		[53]
	DrugMap Central		[43]
	ChemSpider	http://www.chemspider.com
	ChemFrog	http://www.chemfrog.com
	ChemDB	http://www.chemdb.com
	iScienceSearch	http://cwmglobalsearch.com/gs/Default.aspx
	Chemicalize (ChemAxon)	http://www.chemicalize.org
	DistilBio	http://distilbio.com
Target 3D structure	PDB	http://www.rcsb.org
	OCA	http://oca.weizmann.ac.il/oca-bin/ocamain
	OPM (membrane proteins)	http://opm.phar.umich.edu
	Proteopedia	http://proteopedia.org
	TOPSAN	http://www.topsan.org
Drug-target information	Drugbank		[51]
	TTD		[52]
	PharmGKB		[53]
	DrugMap Central		[43]
	MATADOR (manually annotated)	http://matador.embl.de
	SuperTarget		[54]
	STITCH		[55]
	GLIDA		[56]
	PDSP Ki		[57]
	BindingDB		[58]
Adverse effects and clinical trial information	SIDER		[59]
	FAERS (US FDA)	http://www.fda.gov/Drugs/
	Adverse Reaction Database (Canada)	http://www.hc-sc.gc.ca
	IDIS	http://itsnt14.its.uiowa.edu
	Clinicaltrial.gov	http://clinicaltrials.gov
	DrugMap Central		[43]
FDA label information	FDALABEL(US FDA)
	DailyMed (US FDA)
	SPL (US FDA)
	DrugMap Central		[43]
Pathway information	NCI PID		[60]
	KEGG		[61]
	BioCarta	http://www.biocarta.com
	Reactome	http://www.reactome.org
	PathwayCommons		[62]
	DrugMap Central		[43]
Protein interaction information	HPRD		[63]
	BioGRID		[64]
	STRING		[65]
	PathwayCommons		[62]
	MIPS		[66]
	IntAct		[67]
	DIP		[68]
Molecular omics data	NCBI-GEO	http://www.ncbi.nlm.nih.gov/geo/
	SRA	http://www.ncbi.nlm.nih.gov/Traces/sra/)
	Stanford Microarray Database	http://smd.princeton.edu
	ArrayExpress	http://www.ebi.ac.uk/arrayexpress/)
	PUMAdb	http://puma.princeton.edu
	CellMiner (for NCI-60)	http://discover.nci.nih.gov/cellminer/
	Oncomine	https://www.oncomine.org
	CCLE		[39]
Genetic data or information	dbSNP	http://www.ncbi.nlm.nih.gov/projects/SNP/)
	SRA	http://www.ncbi.nlm.nih.gov/Traces/sra/),
	OMIM		[69]
Drug omics data	CMAP		[38]
	CCLE		[39]
	NCBI-GEO	http://www.ncbi.nlm.nih.gov/geo/)
	SRA	http://www.ncbi.nlm.nih.gov/Traces/sra/)