Table 2.

Gene change comparing EA inhibitory group with control group

Signal pathway	Gene	Sites	EA/control (Fold change)	EA/control (Fold up- or down-regulation)
PKC	IL1R2	F09	0.24	-4.26
PKC	MMP9	F11	0.21	-4.68

Fold-change (2^-ΔΔCt) is the normalized gene expression (2^-ΔCt) in the test sample divided by the normalized gene expression (2^-ΔCt) in the control sample. Fold-regulation represents the fold-change results in a biologically meaningful way. Fold-change values greater than one indicate a positive- or up-regulation, and the fold-regulation is equal to the fold-change. Fold-change values less than one indicate a negative or down-regulation, and the fold-regulation is the negative inverse of the fold-change.