Table 2.
Effect of MAPT rs242562 and GSK3B rs334558 on risk for PD
| SNPs | OR (95% CI) | P | Crude OR (95% CI) | P | Adjusted OR (95% CI)* | P | Crude OR (95% CI) | P | Adjusted OR (95% CI)* | P |
|---|---|---|---|---|---|---|---|---|---|---|
| rs242562 (A/G) |
Allele-wise A vs. G |
|
AA vs. AG + GG |
|
AA vs. AG + GG |
|
AG + AA vs. GG |
|
AG + AA vs. GG |
|
| |
1.278 (0.980-1.666) |
0.071 |
1.087 (0.711 – 1.662) |
0.7 |
1.065 (0.693 – 1.636) |
0.775 |
1.853 (1.169 – 2.936) |
0.009 |
1.785 (1.116 – 2.853) |
0.016 |
| Power |
0.266 |
|
0.058 |
|
0.048 |
|
0.793 |
|
0.745 |
|
| rs334558 (T/C) |
Allele-wise T vs. C |
|
TT vs. CT + CC |
|
TT vs. CT + CC |
|
CT + TT vs.CC |
|
CT + TT vs. CC |
|
| |
1.060 (0.814-1.381) |
0.667 |
1.080 (0.612 – 1.907) |
0.79 |
1.018 (0.573 – 1.808) |
0.951 |
1.088 (0.746 – 1.588) |
0.661 |
1.058 (0.719 – 1.557) |
0.774 |
| Power | 0.05 | 0.044 | 0.029 | 0.064 | 0.064 |
* All the OR and P values were adjusted for age and gender.