Figure 5.

There was a statistically significant reduction in the number of CMMCs that occurred per minute in full segments of colon (that lacked luminal contents) compared with the same segments that contained multiple endogenous pellets. (A) empty preparations which had hooks applied and 1 gm tension imposed induced a significant increase in CMMC frequency (compare Empty data set with Hooked data). “Tied” refers to when the colon is cannulated at the oral and anal ends with suture thread and “clipped” refers to when the preparations have stainless steel clips to pinch the bowel wall (e.g., Figure 1B). (B) the extent of propagation of individual CMMCs was significantly increased preparations were hooked and resting tension imposed, compared with the same preparations empty. (C) There was a statistically significant reduction in the propagation velocity of CMMCs between full and empty preparations. When these same preparations were then stimulated with one of the two conventional techniques, tied or hooked, CMMC velocity significantly increased.