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. 2014 Apr 23;13:86. doi: 10.1186/1476-4598-13-86

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Copyright © 2014 Ji et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Association between miR-181a expression in tumors and overall survival in CRC using qRT-PCR. (A) The levels of miR-181a in 137 CRC tissues (Validation Cohort 1) were significantly higher than those in matched adjacent normal tissues; (B) The levels of miR-181a were significantly higher in patients with synchronous (PSLM) and metachronous liver metastasis (PMLM) than those without liver metastasis (PNM); (C-E) The expression levels of miR-181a were positively correlated with advanced TNM stages, T stage and N stage. Expression of miR-181a was presented in log10 scale and was normalised against an endogenous reference U6; (F) Kaplan-Meier overall survival curves for CRC patients were compared according to miR-181a expression level. Patients with higher miR-181a expression displayed a shorter overall survival after surgery. (G-I) The expressions of miR-181b-d in 21 paired CRC patients with and without liver metastasis by qPCR.