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. Author manuscript; available in PMC: 2014 May 15.
Published in final edited form as: Circ Res. 2014 Mar 28;114(7):1185–1203. doi: 10.1161/CIRCRESAHA.114.301597

Figure 7. Arachidonate metabolism to form eicosanoids and prostaglandins by COX-1 in platelets.

Figure 7

AA, liberated by PLA2, is oxidized by COX-1 to form PGG2, then PGH2. PGH2 is further metabolized by thromboxane synthase (TXS) to TXA2, which rapidly decomposes to TXB2. PGH2 can also decompose to PGE2, PGD2 and HHT. Separately, AA can be oxidized by 12-LOX to 12-HETE.