Table 1.
Comparison among m-HMM with and without change point adjustment, and original HMM in simulation study 1
| m-HMM | m-HMM no adj. | original HMM | ||
|---|---|---|---|---|
| Gain |
Sensitivity |
0.917 |
0.915 |
0.863 |
| EFNR |
0.097 |
0.174 |
0.751 |
|
| Normal |
Specificity |
0.996 |
0.994 |
0.945 |
| EFPR |
0.002 |
0.002 |
0.003 |
|
| Loss |
Sensitivity |
0.858 |
0.831 |
0.826 |
| EFNR |
0.309 |
0.434 |
0.846 |
|
| Absent | Sensitivity |
0.960 |
0.857 |
0.810 |
| EFNR | 0.011 | 0.005 | 0.000 |
Sensitivities and empirical false negative rates for copy number gain, loss and absent states, as well as specificities and empirical false positive rates for the normal state in the first simulation study.