Table 2.
Repeatability of hematology data and selected serum proteins
| |
Parameter |
Unit |
r |
ICC |
Healthy smokers |
COPD smokers |
Healthy vs. COPD |
2006/2007 vs. 2012
$
|
|||
|---|---|---|---|---|---|---|---|---|---|---|---|
| |
2006/2007
#
|
2012& |
All |
Healthy |
COPD |
||||||
| smokers | smokers | ||||||||||
| Whole blood |
Leukocytes |
109/L |
0.84 |
0.85 |
7.1 (4.8-7.9) |
7.4 (6.8-9.3) |
|
|
|
|
|
| Neutrophils |
(%) |
0.54 |
0.50 |
54.3 (51.4-63.8) |
62.6 (58.4-64.4) |
|
|
|
|
|
|
| Monocytes |
(%) |
0.72 |
0.70 |
8.4 (8.2-9.0) |
7.7 (6.9-9.4) |
|
|
|
p = 0.03 |
|
|
| Erythrocytes |
1012/L |
0.79 |
0.78 |
4.8 (4.6-5.0) |
4.8 (4.5-5.0) |
|
|
|
|
|
|
| Thrombocytes |
109/L |
0.86 |
0.86 |
248.0 (208.0-272.0) |
208.0 (176.0-257.0) |
|
|
|
|
|
|
| Anisocytosis |
|
0.81 |
0.82 |
45.0 (43.0-47.0) |
46.0 (46.0-47.0) |
p = 0.014 |
|
|
|
|
|
| Hemoglobin |
g/dL |
0.80 |
0.81 |
14.8 (14.0-15.1) |
15.0 (14.2-15.7) |
|
|
|
|
|
|
| Hematocrit |
% |
0.73 |
0.73 |
44.0 (42.0-44.0) |
44.0 (43.0-47.0) |
|
|
|
|
|
|
| MCH |
pg |
0.83 |
0.68 |
30.8 (29.2-31.9) |
31.5 (30.7-32.6) |
|
|
p < 0.001 |
p = 0.03 |
p < 0.005 |
|
| MCV |
109 μL |
0.91 |
0.91 |
89.1 (87.0-94.8) |
93.0 (91.1-94.4) |
p = 0.008 |
|
|
|
|
|
| Serum |
Serum creatinine |
mg/dL |
0.88 |
0.71 |
0.9 (0.8-1.0) |
0.8 (0.7-0.9) |
|
|
p = 0.006 |
p = 0.003 |
|
| ALP |
U/L |
0.86 |
0.78 |
79.0 (65.0-95.0) |
89.0 (70.5-97.5) |
|
|
|
|
|
|
| AST/GOT |
U/L |
0.68 |
0.79 |
25.0 (24.0-30.0) |
23.5 (20.5-29.5) |
|
|
|
|
|
|
| ALT/GPT |
U/L |
0.67 |
0.58 |
23.0 (21.0-38.0) |
21.5 (18.5-33.5) |
|
|
|
|
|
|
| G-GT |
U/L |
0.87 |
0.82 |
27.0 (20.0-30.0) |
42.5 (22.0-56.0) |
p = 0.09 |
p = 0.05 |
p = 0.01 |
|
p = 0.03 |
|
| LTB4 |
μg/mL |
0.01 |
−0.02 |
1.5 (0.9-2.1) |
1.6 (1.2-2.0) |
m: p = 0.0051 |
|
nd |
nd |
nd |
|
| A1AT |
ng/mL |
0.74 |
−0.53 |
767.9 (707.5-844.5) |
870.9 (828.8-906.6) |
m: p = 0.014 |
p = 0.02 |
nd |
nd |
nd |
|
| IL6 |
pg/mL |
0.25 |
−0.34 |
1.6 (1.1-3.4) |
3.2 (2.0-4.0) |
p = 0.002 |
p = 0.02 |
nd |
nd |
nd |
|
| VWF | U/mL | 0.69 | 0.67 | 1.3 (1.1-1.6) | 1.8 (1.6-2.0) | p = 0.003 | p = 0.004 | ||||
MCH: mean corpuscular/cellular hemoglobin. MCV: mean corpuscular/cell volume, ALT/GPT:Alanin-Aminotransferase/Glutamat-Pyruvat-Transaminase.
AST/GOT: Aspartat-Aminotransferase/Glutamat-Oxalacetat-Transaminase, ALP: Alkaline phosphatase, GGT: Gamma-glutamyltransferase.
#Roepcke et al. PLOS One 2012 [1] Table 4/Table S8. m = male subjects, & Mann–Whitney-U-test, $ Wilcoxon-test.
r = correlation coeficient. ICC = intraclass correlation coeficient comparing 2006/2007 and 2012 data of all subjects.
nd = not done. due to deviations based on differences in ELISA batches.