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. 2014 Apr 15;13:56. doi: 10.1186/1475-2859-13-56

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Copyright © 2014 Matsuda et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Cell wall-permeability barriers to the recombinant Fab(H+L) secretion by C. glutamicum. HC and LC of the Fab fragment are secreted through the cytoplasmic membrane by the Sec machinery and form a heterodimer with an intermolecular disulfide bond (S–S) in the extracellular space. There are at least two crucial permeability barriers (X) interrupting Fab secretion; the PG-arabinogalactan layer synthesized by PBP1a and the S-layer composed of CspB. These two structures also function as permeability barriers to lysozyme.