Table 1.
Effects of Continuous Hyperoxia on Distal Lung Structure from Birth through to P14, as Well as Brief Hyperoxia from P0 to P4 followed by Recovery in Room Air through P28
| Postnatal age-exposure (N) | MLI (μm) | Nodal density (points per mm2) | Septal thickness (μm) |
|---|---|---|---|
| P4-O2 (5) | 74.66 ± 1.93a | 937 ± 36a | 11.34 ± 0.68a |
| P4-RA (4) | 66.62 ± 0.65 | 1160 ± 27 | 14.07 ± 0.59 |
| P7-O2 (4) | 83.22 ± 2.87a | 847 ± 46a | 12.35 ± 1.0a |
| P7-RA (4) | 69.96 ± 1.74 | 1230 ± 95 | 19.54 ± 0.69 |
| P14-O2 (3) | 92.70 ± 3.56a | 680 ± 24a | 9.67 ± 0.14a |
| P14-RA (4) | 61.75 ± 1.57 | 1720 ± 118 | 16.21 ± 1.10 |
| P28-O2(P0–P4) (3) | 56.82 ± 0.62a | 1861 ± 74a | 12.02 ± 0.96a |
| P28-RA (4) | 51.01 ± 0.52 | 2103 ± 44.53 | 14.98 ± 0.35 |
Values are means ± SEM.
a
Significant differences analyzed by Student–s t test (p < 0.05 vs. RA at equivalent postnatal ages).
MLI, mean linear intercept; O2, 85% hyperoxia; RA, room-air.