Table 2.
Outcomes |
No. of patients with events (percent) |
Adjusted a RR (95% CI) | |
---|---|---|---|
ACEi/ARB users |
Non-users |
||
(N = 101,494) | (N = 135,714) | ||
AKI-D |
438 (0.43%) |
372 (0.27%) |
0.83 (0.71, 0.98) |
All-cause mortality | 4,654 (4.59%) | 6,435 (4.74%) | 0.91 (0.87, 0.95) |
ACEi: Angiotensin converting enzyme inhibitor; ARB: Angiotensin receptor blocker; RR: Relative Risk; CI: Confidence Interval; AKI-D: Acute kidney injury treated with dialysis.
Outcomes: (1) Primary outcome: AKI-D (within 14 days of surgery); (2) Secondary outcome: All-cause mortality (within 90 days of surgery).
Relative risk was calculated for preoperative ACEi/ARB use compared to non-use.
aAdjusted for age, sex, chronic kidney disease, coronary artery disease, congestive heart failure, cerebrovascular disease, peripheral vascular disease, chronic obstructive pulmonary disease, chronic liver disease, anti-diabetic agents, beta-adrenergic blockers, calcium channel blockers, non-potassium sparing diuretics, statins, type of surgery (cardiac, vascular, thoracic, abdominal, retro-peritoneal), era of surgery (1995 to 1998, 1999 to 2001, 2002 to 2004, 2005 to 2007, 2008 to 2010).