Table 4.
Mean longevity of adult flies with the misexpression of reduced-lifespan genes in specific adult tissues
| Reduced-lifespan gene | GS line. no. |
GAL4 driver line |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| P{GawB}l(3)31-1 31–1 | 48Y-GAL4 | 24B-GAL4 | NP5021 | byn-GAL4 | drm-GAL4 | Cg-GAL4 | P{GawB}5108 | ||
|
Transportin |
11030 |
33.4 |
33.5 |
32.7 |
15.6 |
39.8 |
33.5 |
25.6 |
33.0 |
|
Dream |
16231 |
29.1 |
34.7 |
3.0 |
4.6 |
21.8 |
25.2 |
30.9 |
(30.0) |
|
CG10277 |
11124 |
35.4 |
32.5 |
23.4 |
7.6 |
25.1 |
27.9 |
27.9 |
32.1 |
|
Hepatocyte nuclear factor 4 |
10535 |
37.8 |
29.1 |
27.7 |
13.8 |
25.3 |
30.2 |
31.6 |
35.5 |
|
Calpain-A |
9176 |
30.0 |
(37.8) |
23.5 |
17.8 |
(19.5) |
21.3 |
23.5 |
29.4 |
|
Transfer RNA:ile:49Fb |
14941 |
33.3 |
(19.2) |
33.7 |
4.1 |
28.8 |
31.2 |
29.0 |
36.8 |
|
Combgap |
11121 |
27.6 |
28.8 |
5.5 |
20.1 |
7.8 |
20.5 |
30.7 |
(28.8) |
|
trpγ |
16894 |
33.2 |
31.0 |
31.0 |
19.2 |
30.8 |
27.0 |
35.3 |
(31.2) |
|
Apontic |
15217 |
9.4 |
27.9 |
36.3 |
7.8 |
34.4 |
29.1 |
31.7 |
25.5 |
|
Cadmus |
14710 |
33.3 |
35.3 |
38.2 |
26.7 |
36.9 |
21.0 |
26.6 |
34.3 |
|
PolyA-binding protein |
15168 |
33.0 |
32.1 |
9.3 |
5.3 |
23.2 |
29.8 |
26.3 |
35.1 |
|
Embryonic lethal abnormal vision |
5211 |
27.7 |
31.1 |
6.0 |
30.0 |
12.2 |
33.0 |
26.6 |
31.5 |
|
CG3363 |
11052 |
20.7 |
18.5 |
8.8 |
11.6 |
22.4 |
19.5 |
21.0 |
33.9 |
|
Stonewall |
8015 |
24.8 |
33.4 |
12.6 |
10.2 |
18.7 |
32.6 |
17.1 |
36.0 |
|
Degringolade |
15270 |
22.6 |
33.3 |
20.1 |
9.2 |
17.0 |
11.6 |
29.7 |
36.5 |
|
Atlastin |
17467 |
8.5 |
35.1 |
27.3 |
16.2 |
17.3 |
31.7 |
30.2 |
42.2 |
|
Chromator |
16669 |
25.5 |
17.1 |
5.3 |
13.1 |
9.6 |
9.6 |
14.6 |
(27.0) |
|
Slipper |
7470 |
13.1 |
14.8 |
7.3 |
26.8 |
21.9 |
25.5 |
8.1 |
26.7 |
|
Polo |
16634 |
30.9 |
13.6 |
29.6 |
24.3 |
24.9 |
35.1 |
28.8 |
35.6 |
|
Without children |
10711 |
27.3 |
38.1 |
16.3 |
8.1 |
22.3 |
26.3 |
16.7 |
29.0 |
|
Heterogeneous nuclear ribonucleoprotein at 27C |
13072 |
18.5 |
13.8 |
6.0 |
13.8 |
5.1 |
15.6 |
25.8 |
33.5 |
|
High mobility group protein D |
10665 |
10.4 |
6.9 |
3.0 |
6.0 |
5.4 |
21.6 |
23.4 |
29.2 |
|
Fmr1 |
11947 |
30.0 |
21.4 |
5.8 |
14.8 |
15.0 |
23.7 |
14.5 |
(36.6) |
|
Peroxin 16 |
12435 |
34.3 |
32.0 |
24.0 |
12.8 |
32.4 |
18.6 |
31.7 |
(21.6) |
|
Pipsqueak |
12449 |
27.3 |
30.4 |
7.7 |
6.0 |
25.4 |
30.5 |
29.4 |
29.0 |
|
CG8290 |
12665 |
32.1 |
21.7 |
19.2 |
26.4 |
16.4 |
33.6 |
32.4 |
37.0 |
|
Vacuolar H + ATPase subunit 100-2 |
10911 |
35.8 |
(35.4) |
34.2 |
26.4 |
24.4 |
29.1 |
35.3 |
(37.2) |
|
CG10321 |
10668 |
24.6 |
35.0 |
12.0 |
10.5 |
13.4 |
35.3 |
19.3 |
32.8 |
|
Roadkill |
15233 |
32.9 |
38.5 |
27.9 |
31.1 |
34.1 |
32.8 |
31.4 |
(35.3) |
|
Lamin |
16890 |
21.5 |
22.5 |
21.6 |
6.0 |
12.2 |
17.8 |
10.9 |
23.9 |
|
Elfless |
15946 |
30.6 |
28.4 |
22.8 |
20.6 |
20.6 |
31.4 |
29.9 |
34.4 |
|
CG16779 |
9601 |
26.9 |
34.5 |
11.7 |
16.5 |
31.2 |
34.5 |
18.0 |
45.0 |
|
Elongation factor Tu mitochondrial |
11862 |
29.0 |
28.3 |
23.3 |
22.8 |
31.5 |
15.5 |
31.3 |
(27.6) |
|
CG11819 |
5065 |
31.1 |
35.0 |
31.5 |
7.5 |
28.1 |
30.2 |
32.1 |
34.7 |
|
Autophagy-specific gene 1 |
15847 |
29.5 |
34.2 |
32.6 |
14.7 |
28.1 |
27.2 |
31.7 |
37.8 |
|
CG8032 |
5196 |
38.4 |
28.4 |
33.9 |
12.6 |
30.0 |
35.1 |
28.8 |
32.0 |
|
N-methyl-D-aspartate receptor-associated protein |
16440 |
27.6 |
5.5 |
15.4 |
15.8 |
20.6 |
16.7 |
23.9 |
31.5 |
|
Src oncogene at 42A |
11049 |
21.6 |
21.9 |
17.1 |
9.8 |
19.2 |
24.6 |
16.1 |
33.0 |
|
CG30482 |
9799 |
32.8 |
37.4 |
30.8 |
31.1 |
29.3 |
9.9 |
13.8 |
35.8 |
| Canton-S (control) | 37.6 | 32.9 | 34.9 | 31.5 | 31.8 | 35.7 | 28.4 | 34.4 | |
Bold numbers indicate longevity less than 1/3 of control. Parenthetical numbers indicate the mean longevity obtained from fewer than five flies.