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Excess adenosine contributes to reduced PDE5 mRNA levels and PDE activity in two independent priapic animal models. A, B) PDE5 mRNA levels (A) and PDE activity (B) were significantly reduced to a similar extent in penile tissues of SCD Tg and ADA−/− mice. C, D) PDE5 mRNA levels (C) and PDE activity (D) were restored to normal levels by chronic PEG-ADA treatment. Data are expressed as means ± sem; n = 6. *P < 0.05 vs. control mice; **P < 0.05 vs. untreated ADA−/− or SCD mice.
