Figure 3.

PEG-ADA enzyme therapy reduces priapic features seen in ADA^−/− and SCD Tg mice. A) Representative recordings of ICP induced by CNS at 2 V for 1 min in control, ADA^−/−, and SCD Tg mice in the absence of treatment or following 2 wk treatment with PEG-ADA. B) Maximum ICP normalized to MAP. C) Area under curve (mmHg·s) post-CNS (2 V). See Materials and Methods for details regarding PEG-ADA treatments. *P < 0.05 vs. control mice; **P < 0.05 vs. ADA^−/− mice; ^##P < 0.05 vs. SCD Tg mice; n = 4–6.